uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
values |
|---|---|---|---|---|---|---|---|---|
Q1.1450 | Q1 | Is TNFRSF4 a druggable gene? | There are currently no approved drugs targeting TNFRSF4, but there are 5 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TNFRSF4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3441', 'drugName': 'Ivuxolimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4001', 'drugName': 'Khk-4083', 'drugIsApproved': False, 'newLinkedTargets_string': 'TNFRSF4 (ENSG00000186827)', 'maxCl... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.78 | Q1 | Is ARAF a druggable gene? | There are currently no approved drugs targeting ARAF, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ARAF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4331', 'drugName': 'Tovorafenib', 'drugIsApproved': False, 'newLinkedTargets_string': 'RAF1 (ENSG00000132155), BRAF (ENSG00000157764), ARAF (ENSG00000078061)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3033', 'drugName': 'Belvarafenib', 'drugIsApproved': False, 'newLinkedTa... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1016 | Q1 | Is NTSR1 a druggable gene? | There are currently no approved drugs targeting NTSR1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NTSR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4907', 'drugName': 'Reminertant', 'drugIsApproved': False, 'newLinkedTargets_string': 'NTSR1 (ENSG00000101188)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.664 | Q1 | Is IKBKB a druggable gene? | There are currently no approved drugs targeting IKBKB, but there are 7 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IKBKB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4921', 'drugName': 'Bardoxolone Methyl', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFE2L2 (ENSG00000116044), KEAP1 (ENSG00000079999), PPARG (ENSG00000132170), IKBKB (ENSG00000104365)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4920', 'drugName': 'Bardoxolone Meth... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1140 | Q1 | Is PRKCI a druggable gene? | There is 1 drug, Midostaurin, that targets PRKCI, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRKCI %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5666', 'drugName': 'Midostaurin', 'drugIsApproved': True, 'newLinkedTargets_string': 'KIT (ENSG00000157404), KDR (ENSG00000128052), PDGFRB (ENSG00000113721), PDGFRA (ENSG00000134853), FLT3 (ENSG00000122025), PRKD3 (ENSG00000115825), PRKCI (ENSG00000163558), PRKCA (ENSG00000154229), PRKCG (... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.988 | Q1 | Is NOS3 a druggable gene? | There are currently no approved drugs targeting NOS3, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NOS3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_890', 'drugName': 'Tilarginine', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOS1 (ENSG00000089250), NOS2 (ENSG00000007171), NOS3 (ENSG00000164867)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_1662', 'drugName': 'Tilarginine Acetate', 'drugIsApproved': False, 'newLi... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1421 | Q1 | Is TFR2 a druggable gene? | There are currently no approved drugs targeting TFR2, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TFR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3234', 'drugName': 'Pabinafusp Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'TFRC (ENSG00000072274), TFR2 (ENSG00000106327)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_4473', 'drugName': 'E2.3', 'drugIsApproved': False, 'newLinkedTargets_string': 'TFRC (ENSG00... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1509 | Q1 | Is TUBB8B a druggable gene? | There are currently no approved drugs targeting TUBB8B, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TUBB8B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3400', 'drugName': 'Abt-751', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBB3 (ENSG00000258947), TUBB4A (ENSG00000104833), TUBB8 (ENSG00000261456), TUBB (ENSG00000196230), TUBB2A (ENSG00000137267), TUBB2B (ENSG00000137285), TUBB... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1345 | Q1 | Is SELE a druggable gene? | There are currently no approved drugs targeting SELE, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SELE %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2473', 'drugName': 'Rivipansel', 'drugIsApproved': False, 'newLinkedTargets_string': 'SELE (ENSG00000007908), SELP (ENSG00000174175), SELL (ENSG00000188404)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_2474', 'drugName': 'Rivipansel', 'drugIsApproved': False, 'newLinkedTarge... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1197 | Q1 | Is PTGS1 a druggable gene? | There are currently 61 approved drugs which target PTGS1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PTGS1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2814', 'drugName': 'Dipyrone', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (ENSG00000073756), PTGS1 (ENSG00000095303)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5291', 'drugName': 'Naproxen Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGS2 (E... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1215 | Q1 | Is RELA a druggable gene? | There are currently no approved drugs targeting RELA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RELA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1568', 'drugName': 'Edasalonexent', 'drugIsApproved': False, 'newLinkedTargets_string': 'NFKB2 (ENSG00000077150), NFKB1 (ENSG00000109320), RELA (ENSG00000173039)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.632 | Q1 | Is HTT a druggable gene? | There are currently no approved drugs targeting HTT, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTT %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3493', 'drugName': 'Tominersen', 'drugIsApproved': False, 'newLinkedTargets_string': 'HTT (ENSG00000197386)', 'maxClinicalTrialPhase': 3}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.396 | Q1 | Is EGLN3 a druggable gene? | There is 1 drug, Roxadustat, that targets EGLN3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EGLN3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5393', 'drugName': 'Roxadustat', 'drugIsApproved': True, 'newLinkedTargets_string': 'EGLN2 (ENSG00000269858), P4HTM (ENSG00000178467), EGLN1 (ENSG00000135766), EGLN3 (ENSG00000129521)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_2677', 'drugName': 'Daprodustat', 'drugIsAppro... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1489 | Q1 | Is TSHR a druggable gene? | There are currently 2 approved drugs which target TSHR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TSHR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2659', 'drugName': 'Thyrotropin Alfa', 'drugIsApproved': True, 'newLinkedTargets_string': 'TSHR (ENSG00000165409)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3423', 'drugName': 'Thyrotropin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TSHR (ENSG00000165409)', 'maxC... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.517 | Q1 | Is GHR a druggable gene? | There are currently 6 approved drugs which target GHR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GHR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3588', 'drugName': 'Somapacitan', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1805', 'drugName': 'Pegvisomant', 'drugIsApproved': True, 'newLinkedTargets_string': 'GHR (ENSG00000112964)', 'maxClinical... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.630 | Q1 | Is HTR6 a druggable gene? | There are currently 5 approved drugs which target HTR6, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HTR6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2863', 'drugName': 'Dexfenfluramine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HTR1F (ENSG00000179097), HTR2B (ENSG00000135914), HTR4 (ENSG00000164270), HTR1B (ENSG00000135312), HTR3A (ENSG00000166736), HTR1A (ENSG00000178394), HTR1D (ENSG00000179546), HTR2A (ENSG00000102468), H... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1122 | Q1 | Is PRIM1 a druggable gene? | There are currently 5 approved drugs which target PRIM1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRIM1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4', 'drugName': 'Gemcitabine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.31 | Q1 | Is ADORA3 a druggable gene? | There are currently 8 approved drugs which target ADORA3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADORA3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5471', 'drugName': 'Aminophylline', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650), PDE3A (ENSG00000172572), PDE3B (ENSG00000152270), ADORA1 (ENSG00000163485), ADORA2B (ENSG00000170425),... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.50 | Q1 | Is AKT2 a druggable gene? | There are currently no approved drugs targeting AKT2, but there are 14 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AKT2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2935', 'drugName': 'Ipatasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'AKT2 (ENSG00000105221), AKT3 (ENSG00000117020), AKT1 (ENSG00000142208)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6037', 'drugName': 'Capivasertib', 'drugIsApproved': False, 'newLinkedTa... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.242 | Q1 | Is CDK20 a druggable gene? | There are currently no approved drugs targeting CDK20, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CDK20 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1429', 'drugName': 'Roniciclib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.431 | Q1 | Is ESR2 a druggable gene? | There are currently 22 approved drugs which target ESR2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ESR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1689', 'drugName': 'Toremifene Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'ESR2 (ENSG00000140009), ESR1 (ENSG00000091831)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4127', 'drugName': 'Diethylstilbestrol Diphosphate', 'drugIsApproved': True, 'newLinkedTar... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.353 | Q1 | Is CYSLTR1 a druggable gene? | There are currently 3 approved drugs which target CYSLTR1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CYSLTR1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2453', 'drugName': 'Montelukast Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3211', 'drugName': 'Zafirlukast', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYSLTR1 (ENSG00000173198)... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.126 | Q1 | Is C1S a druggable gene? | There are currently 2 approved drugs which target C1S, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%C1S %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2064', 'drugName': 'Human C1-Esterase Inhibitor', 'drugIsApproved': True, 'newLinkedTargets_string': 'C1S (ENSG00000182326), F11 (ENSG00000088926), KLKB1 (ENSG00000164344), F12 (ENSG00000131187)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3495', 'drugName': 'Sutimlimab', 'd... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.554 | Q1 | Is GRIN3B a druggable gene? | There are currently 14 approved drugs which target GRIN3B, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GRIN3B %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6209', 'drugName': 'Orphenadrine Citrate', 'drugIsApproved': True, 'newLinkedTargets_string': 'GRIN1 (ENSG00000176884), GRIN2A (ENSG00000183454), GRIN2B (ENSG00000273079), GRIN2D (ENSG00000105464), GRIN3B (ENSG00000116032), GRIN2C (ENSG00000161509), GRIN3A (ENSG00000198785), HRH1 (ENSG0000... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1502 | Q1 | Is TUBB2A a druggable gene? | There are currently 20 approved drugs which target TUBB2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TUBB2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1084', 'drugName': 'Brentuximab Vedotin', 'drugIsApproved': True, 'newLinkedTargets_string': 'TNFRSF8 (ENSG00000120949), TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG000... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.71 | Q1 | Is APH1A a druggable gene? | There are currently no approved drugs targeting APH1A, but there are 6 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%APH1A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5562', 'drugName': 'Nirogacestat', 'drugIsApproved': False, 'newLinkedTargets_string': 'APH1A (ENSG00000117362), PSENEN (ENSG00000205155), APH1B (ENSG00000138613), PSEN1 (ENSG00000080815), NCSTN (ENSG00000162736), PSEN2 (ENSG00000143801)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTar... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1118 | Q1 | Is PPP2CA a druggable gene? | There are currently no approved drugs targeting PPP2CA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PPP2CA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4335', 'drugName': 'Lb-100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PPP2CA (ENSG00000113575), PPP5C (ENSG00000011485), PPP2CB (ENSG00000104695)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_4336', 'drugName': 'Lb-100', 'drugIsApproved': False, 'newLinkedTargets_... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1038 | Q1 | Is PCSK9 a druggable gene? | There are currently 4 approved drugs which target PCSK9, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PCSK9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1637', 'drugName': 'Alirocumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4738', 'drugName': 'Inclisiran Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'PCSK9 (ENSG00000169174)', 'ma... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1097 | Q1 | Is PMEL a druggable gene? | There is 1 drug, Tebentafusp, that targets PMEL, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PMEL %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5977', 'drugName': 'Tebentafusp', 'drugIsApproved': True, 'newLinkedTargets_string': 'PMEL (ENSG00000185664)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5274', 'drugName': 'Imc-Gp100', 'drugIsApproved': False, 'newLinkedTargets_string': 'PMEL (ENSG00000185664), CD3E (ENSG00... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1499 | Q1 | Is TUBA4A a druggable gene? | There are currently 20 approved drugs which target TUBA4A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TUBA4A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3175', 'drugName': 'Eribulin Mesylate', 'drugIsApproved': True, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG0000026... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.569 | Q1 | Is HAO1 a druggable gene? | There are currently 2 approved drugs which target HAO1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HAO1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1382', 'drugName': 'Lumasiran', 'drugIsApproved': True, 'newLinkedTargets_string': 'HAO1 (ENSG00000101323)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1071', 'drugName': 'Lumasiran Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'HAO1 (ENSG00000101323)', 'maxCli... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.344 | Q1 | Is CYP11B2 a druggable gene? | There is 1 drug, Levoketoconazole, that targets CYP11B2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CYP11B2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3930', 'drugName': 'Levoketoconazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'CYP11B1 (ENSG00000160882), CYP11B2 (ENSG00000179142), CYP17A1 (ENSG00000148795), CYP11A1 (ENSG00000140459)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3929', 'drugName': 'Levoketocona... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1533 | Q1 | Is XDH a druggable gene? | There are currently 5 approved drugs which target XDH, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%XDH %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5751', 'drugName': 'Allopurinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'XDH (ENSG00000158125)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6368', 'drugName': 'Oxypurinol', 'drugIsApproved': True, 'newLinkedTargets_string': 'XDH (ENSG00000158125)', 'maxClinicalT... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.937 | Q1 | Is NDUFA11 a druggable gene? | There are currently 2 approved drugs which target NDUFA11, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFA11 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (EN... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.822 | Q1 | Is LILRA4 a druggable gene? | There are currently no approved drugs targeting LILRA4, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LILRA4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2096', 'drugName': 'Daxdilimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'LILRA4 (ENSG00000239961)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.665 | Q1 | Is IL10 a druggable gene? | There are currently no approved drugs targeting IL10, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL10 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4438', 'drugName': 'Sch-708980', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL10 (ENSG00000136634)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1086 | Q1 | Is PIM3 a druggable gene? | There are currently no approved drugs targeting PIM3, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PIM3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_295', 'drugName': 'Sgi-1776', 'drugIsApproved': False, 'newLinkedTargets_string': 'PIM1 (ENSG00000137193), PIM2 (ENSG00000102096), PIM3 (ENSG00000198355)', 'maxClinicalTrialPhase': 1}, {'UUID': 'DrugGeneTargets_v2_3068', 'drugName': 'Azd-1208', 'drugIsApproved': False, 'newLinkedTargets_st... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1352 | Q1 | Is SERPINE1 a druggable gene? | There are currently no approved drugs targeting SERPINE1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SERPINE1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5187', 'drugName': 'Aleplasinin', 'drugIsApproved': False, 'newLinkedTargets_string': 'SERPINE1 (ENSG00000106366)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.496 | Q1 | Is GABRA4 a druggable gene? | There are currently 67 approved drugs which target GABRA4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GABRA4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1108', 'drugName': 'Temazepam', 'drugIsApproved': True, 'newLinkedTargets_string': 'GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256), GABRQ (ENSG00000268089), GABRA3 (ENSG00000011677),... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.484 | Q1 | Is FYN a druggable gene? | There is 1 drug, Dasatinib, that targets FYN, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%FYN %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4602', 'drugName': 'Dasatinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDGFRB (ENSG00000113721), FYN (ENSG00000010810), SRC (ENSG00000197122), LCK (ENSG00000182866), YES1 (ENSG00000176105), BLK (ENSG00000136573), HCK (ENSG00000101336), LYN (ENSG00000254087), FRK (ENSG000001118... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1416 | Q1 | Is TBXAS1 a druggable gene? | There is 1 drug, Picotamide, that targets TBXAS1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TBXAS1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4430', 'drugName': 'Picotamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'TBXAS1 (ENSG00000059377), TBXA2R (ENSG00000006638)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4429', 'drugName': 'Picotamide', 'drugIsApproved': True, 'newLinkedTargets_string': 'TBXAS1 (E... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.948 | Q1 | Is NDUFA9 a druggable gene? | There are currently 2 approved drugs which target NDUFA9, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NDUFA9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1888', 'drugName': 'Metformin Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'GPD2 (ENSG00000115159), MT-ND6 (ENSG00000198695), NDUFA10 (ENSG00000130414), NDUFS8 (ENSG00000110717), MT-ND4L (ENSG00000212907), NDUFA6 (ENSG00000184983), MT-ND1 (ENSG00000198888), NDUFB6 (EN... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1318 | Q1 | Is RXFP1 a druggable gene? | There are currently no approved drugs targeting RXFP1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RXFP1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3540', 'drugName': 'Serelaxin', 'drugIsApproved': False, 'newLinkedTargets_string': 'RXFP1 (ENSG00000171509), RXFP2 (ENSG00000133105)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_3541', 'drugName': 'Serelaxin', 'drugIsApproved': False, 'newLinkedTargets_string': 'RXFP1 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.574 | Q1 | Is HBEGF a druggable gene? | There are currently no approved drugs targeting HBEGF, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HBEGF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5685', 'drugName': 'Khk-2866', 'drugIsApproved': False, 'newLinkedTargets_string': 'HBEGF (ENSG00000113070)', 'maxClinicalTrialPhase': 1}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.354 | Q1 | Is DBH a druggable gene? | There are currently no approved drugs targeting DBH, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DBH %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2943', 'drugName': 'Zamicastat', 'drugIsApproved': False, 'newLinkedTargets_string': 'DBH (ENSG00000123454)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.263 | Q1 | Is CHRM5 a druggable gene? | There are currently 2 approved drugs which target CHRM5, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CHRM5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6292', 'drugName': 'Terodiline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM4 (ENSG00000180720), CHRM1 (ENSG00000168539), CHRM2 (ENSG00000181072), CHRM5 (ENSG00000184984), CACNA1H (ENSG00000196557), CACNA2D1 (ENSG00000153956), CACNA1C (ENSG00000151067)... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.60 | Q1 | Is AMY2A a druggable gene? | There is 1 drug, Acarbose, that targets AMY2A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AMY2A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1144', 'drugName': 'Acarbose', 'drugIsApproved': True, 'newLinkedTargets_string': 'AMY2A (ENSG00000243480), MGAM (ENSG00000257335)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1145', 'drugName': 'Acarbose', 'drugIsApproved': True, 'newLinkedTargets_string': 'AMY2A (ENSG00000... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1249 | Q1 | Is RPL28 a druggable gene? | There is 1 drug, Ataluren, that targets RPL28, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPL28 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1074 | Q1 | Is PGR a druggable gene? | There are currently 26 approved drugs which target PGR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PGR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4281', 'drugName': 'Ulipristal Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PGR (ENSG00000082175)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_470', 'drugName': 'Ulipristal', 'drugIsApproved': True, 'newLinkedTargets_string': 'PGR (ENSG00000082175)', 'maxCli... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1264 | Q1 | Is RPL4 a druggable gene? | There is 1 drug, Ataluren, that targets RPL4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPL4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.261 | Q1 | Is CHRM3 a druggable gene? | There are currently 65 approved drugs which target CHRM3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CHRM3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2497', 'drugName': 'Cevimeline', 'drugIsApproved': True, 'newLinkedTargets_string': 'CHRM3 (ENSG00000133019), CHRM1 (ENSG00000168539)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_3911', 'drugName': 'Acetylcholine Chloride', 'drugIsApproved': True, 'newLinkedTargets_string': ... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.373 | Q1 | Is DRD1 a druggable gene? | There are currently 13 approved drugs which target DRD1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DRD1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4078', 'drugName': 'Pergolide', 'drugIsApproved': True, 'newLinkedTargets_string': 'DRD2 (ENSG00000149295), DRD3 (ENSG00000151577), DRD5 (ENSG00000169676), DRD4 (ENSG00000069696), DRD1 (ENSG00000184845)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_493', 'drugName': 'Methyler... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.299 | Q1 | Is COL4A4 a druggable gene? | There are currently 2 approved drugs which target COL4A4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL4A4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5819', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156),... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.326 | Q1 | Is CSNK2A1 a druggable gene? | There are currently no approved drugs targeting CSNK2A1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CSNK2A1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5963', 'drugName': 'Silmitasertib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CSNK2A1 (ENSG00000101266)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.308 | Q1 | Is COL6A5 a druggable gene? | There are currently 2 approved drugs which target COL6A5, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%COL6A5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5818', 'drugName': 'Ocriplasmin', 'drugIsApproved': True, 'newLinkedTargets_string': 'FN1 (ENSG00000115414), COL1A2 (ENSG00000164692), COL1A1 (ENSG00000108821), COL2A1 (ENSG00000139219), COL3A1 (ENSG00000168542), COL4A1 (ENSG00000187498), COL5A1 (ENSG00000130635), COL6A1 (ENSG00000142156),... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1530 | Q1 | Is VWF a druggable gene? | There are currently 2 approved drugs which target VWF, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%VWF %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4930', 'drugName': 'Von Willebrand Factor Human', 'drugIsApproved': True, 'newLinkedTargets_string': 'VWF (ENSG00000110799)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5507', 'drugName': 'Caplacizumab', 'drugIsApproved': True, 'newLinkedTargets_string': 'VWF (ENSG0000011079... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.52 | Q1 | Is ALAS1 a druggable gene? | There are currently 2 approved drugs which target ALAS1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ALAS1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6332', 'drugName': 'Givosiran', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALAS1 (ENSG00000023330)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5803', 'drugName': 'Givosiran Sodium', 'drugIsApproved': True, 'newLinkedTargets_string': 'ALAS1 (ENSG00000023330)', 'maxC... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1432 | Q1 | Is TIGIT a druggable gene? | There are currently no approved drugs targeting TIGIT, but there are 7 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TIGIT %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2236', 'drugName': 'Ociperlimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TIGIT (ENSG00000181847)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_30', 'drugName': 'Vibostolimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'TIGIT (ENSG00000181847)', 'maxCli... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.801 | Q1 | Is LAG3 a druggable gene? | There is 1 drug, Relatlimab, that targets LAG3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LAG3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2446', 'drugName': 'Relatlimab', 'drugIsApproved': True, 'newLinkedTargets_string': 'LAG3 (ENSG00000089692)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6101', 'drugName': 'Fianlimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'LAG3 (ENSG00000089692)', 'maxClinical... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1256 | Q1 | Is RPL35 a druggable gene? | There is 1 drug, Ataluren, that targets RPL35, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPL35 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.760 | Q1 | Is KCNH6 a druggable gene? | There are currently 5 approved drugs which target KCNH6, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KCNH6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5118', 'drugName': 'Guanidine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNQ1 (ENSG00000053918), KCND3 (ENSG00000171385), KCNH2 (ENSG00000055118), KCNA2 (ENSG00000177301), KCNA1 (ENSG00000111262), KCNQ2 (ENSG00000075043), KCNQ3 (ENSG00000184156), KCNA7 (ENSG000001... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1190 | Q1 | Is PTGDS a druggable gene? | There is 1 drug, Antrafenine, that targets PTGDS, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PTGDS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3195', 'drugName': 'Antrafenine', 'drugIsApproved': True, 'newLinkedTargets_string': 'PTGDS (ENSG00000107317)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.24 | Q1 | Is ADH5 a druggable gene? | There is 1 drug, Nitrefazole, that targets ADH5, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ADH5 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6344', 'drugName': 'Nitrefazole', 'drugIsApproved': True, 'newLinkedTargets_string': 'ADH1A (ENSG00000187758), ADH4 (ENSG00000198099), ADH1B (ENSG00000196616), ADH1C (ENSG00000248144), ADH7 (ENSG00000196344), ADH5 (ENSG00000197894), ADH6 (ENSG00000172955)', 'maxClinicalTrialPhase': 4}, {'U... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.993 | Q1 | Is NOX4 a druggable gene? | There are currently no approved drugs targeting NOX4, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NOX4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5524', 'drugName': 'Setanaxib', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOX4 (ENSG00000086991), NOX1 (ENSG00000007952)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5525', 'drugName': 'Setanaxib', 'drugIsApproved': False, 'newLinkedTargets_string': 'NOX4 (ENSG000... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.418 | Q1 | Is EPHB3 a druggable gene? | There is 1 drug, Vandetanib, that targets EPHB3, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%EPHB3 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1936', 'drugName': 'Vandetanib', 'drugIsApproved': True, 'newLinkedTargets_string': 'TEK (ENSG00000120156), ERBB2 (ENSG00000141736), EGFR (ENSG00000146648), ERBB4 (ENSG00000178568), ERBB3 (ENSG00000065361), EPHA2 (ENSG00000142627), EPHB2 (ENSG00000133216), EPHA5 (ENSG00000145242), EPHA4 (E... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1028 | Q1 | Is P2RY2 a druggable gene? | There are currently no approved drugs targeting P2RY2, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%P2RY2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_799', 'drugName': 'Diquafosol Tetrasodium', 'drugIsApproved': False, 'newLinkedTargets_string': 'P2RY4 (ENSG00000186912), P2RY2 (ENSG00000175591), P2RY6 (ENSG00000171631), P2RY1 (ENSG00000169860)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6160', 'drugName': 'Diquafosol', '... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.635 | Q1 | Is ICOS a druggable gene? | There are currently no approved drugs targeting ICOS, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%ICOS %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3904', 'drugName': 'Feladilimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICOS (ENSG00000163600)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_276', 'drugName': 'Vopratelimab', 'drugIsApproved': False, 'newLinkedTargets_string': 'ICOS (ENSG00000163600)', 'maxClin... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1030 | Q1 | Is P2RY6 a druggable gene? | There are currently no approved drugs targeting P2RY6, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%P2RY6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6159', 'drugName': 'Diquafosol', 'drugIsApproved': False, 'newLinkedTargets_string': 'P2RY4 (ENSG00000186912), P2RY2 (ENSG00000175591), P2RY6 (ENSG00000171631), P2RY1 (ENSG00000169860)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6161', 'drugName': 'Diquafosol', 'drugIsAppro... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1279 | Q1 | Is RPS15 a druggable gene? | There is 1 drug, Ataluren, that targets RPS15, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RPS15 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3776', 'drugName': 'Ataluren', 'drugIsApproved': True, 'newLinkedTargets_string': 'RPSA (ENSG00000168028), RPS27 (ENSG00000177954), RPS6 (ENSG00000137154), RPS2 (ENSG00000140988), RPS3 (ENSG00000149273), RPS3A (ENSG00000145425), RPS4X (ENSG00000198034), RPS4Y1 (ENSG00000129824), RPS5 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.170 | Q1 | Is CALCR a druggable gene? | There are currently 6 approved drugs which target CALCR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CALCR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2396', 'drugName': 'Pramlintide Acetate', 'drugIsApproved': True, 'newLinkedTargets_string': 'CALCR (ENSG00000004948), RAMP1 (ENSG00000132329), RAMP2 (ENSG00000131477), RAMP3 (ENSG00000122679)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1951', 'drugName': 'Calcitonin Human'... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1331 | Q1 | Is SCN11A a druggable gene? | There are currently 78 approved drugs which target SCN11A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SCN11A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3767', 'drugName': 'Phenytoin', 'drugIsApproved': True, 'newLinkedTargets_string': 'SCN1A (ENSG00000144285), SCN5A (ENSG00000183873), SCN4A (ENSG00000007314), SCN7A (ENSG00000136546), SCN2A (ENSG00000136531), SCN9A (ENSG00000169432), SCN3A (ENSG00000153253), SCN11A (ENSG00000168356), SCN8A... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.360 | Q1 | Is DHFR a druggable gene? | There are currently 6 approved drugs which target DHFR, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%DHFR %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_39', 'drugName': 'Pralatrexate', 'drugIsApproved': True, 'newLinkedTargets_string': 'DHFR (ENSG00000228716)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4616', 'drugName': 'Pemetrexed', 'drugIsApproved': True, 'newLinkedTargets_string': 'TYMS (ENSG00000176890), DHFR (ENSG000... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.334 | Q1 | Is CUL4A a druggable gene? | There are currently 3 approved drugs which target CUL4A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CUL4A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_64', 'drugName': 'Thalidomide', 'drugIsApproved': True, 'newLinkedTargets_string': 'CRBN (ENSG00000113851), DDB1 (ENSG00000167986), CUL4A (ENSG00000139842), RBX1 (ENSG00000100387)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4886', 'drugName': 'Pomalidomide', 'drugIsApproved... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1029 | Q1 | Is P2RY4 a druggable gene? | There are currently no approved drugs targeting P2RY4, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%P2RY4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6159', 'drugName': 'Diquafosol', 'drugIsApproved': False, 'newLinkedTargets_string': 'P2RY4 (ENSG00000186912), P2RY2 (ENSG00000175591), P2RY6 (ENSG00000171631), P2RY1 (ENSG00000169860)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6161', 'drugName': 'Diquafosol', 'drugIsAppro... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.239 | Q1 | Is CDK18 a druggable gene? | There are currently no approved drugs targeting CDK18, but there are 4 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CDK18 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1429', 'drugName': 'Roniciclib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK4 (ENSG00000135446), CDK2 (ENSG00000123374), CDK5 (ENSG00000164885), CDK6 (ENSG00000105810), CDK7 (ENSG00000134058), CDK3 (ENSG00000250506), CDK16 (ENSG00000102225), CDK18 (ENSG... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.906 | Q1 | Is MST1R a druggable gene? | There are currently no approved drugs targeting MST1R, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MST1R %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5366', 'drugName': 'Glesatinib', 'drugIsApproved': False, 'newLinkedTargets_string': 'MET (ENSG00000105976), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), TEK (ENSG00000120156), MST1R (ENSG00000164078)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_536... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.790 | Q1 | Is KIR2DL1 a druggable gene? | There are currently no approved drugs targeting KIR2DL1, but there are 2 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%KIR2DL1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4725', 'drugName': 'Iph-2101', 'drugIsApproved': False, 'newLinkedTargets_string': 'KIR2DL2 (ENSG00000275546), KIR2DL1 (ENSG00000125498), KIR2DL3 (ENSG00000243772)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_5180', 'drugName': 'Lirilumab', 'drugIsApproved': False, 'newLinke... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.525 | Q1 | Is GLRB a druggable gene? | There are currently 6 approved drugs which target GLRB, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GLRB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5597', 'drugName': 'Isoflurane', 'drugIsApproved': True, 'newLinkedTargets_string': 'KCNK10 (ENSG00000100433), KCNK9 (ENSG00000169427), GABRA1 (ENSG00000022355), GABRB2 (ENSG00000145864), GABRG2 (ENSG00000113327), GABRB3 (ENSG00000166206), GABRA4 (ENSG00000109158), GABRG3 (ENSG00000182256)... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1431 | Q1 | Is TIE1 a druggable gene? | There are currently no approved drugs targeting TIE1, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%TIE1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1414', 'drugName': 'Cp-459632', 'drugIsApproved': False, 'newLinkedTargets_string': 'TIE1 (ENSG00000066056), FLT1 (ENSG00000102755), FLT4 (ENSG00000037280), KDR (ENSG00000128052), FGFR3 (ENSG00000068078), FGFR1 (ENSG00000077782), FGFR4 (ENSG00000160867), FGFR2 (ENSG00000066468)', 'maxClini... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.101 | Q1 | Is BCHE a druggable gene? | There are currently 5 approved drugs which target BCHE, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%BCHE %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3733', 'drugName': 'Propanidid', 'drugIsApproved': True, 'newLinkedTargets_string': 'ACHE (ENSG00000087085), BCHE (ENSG00000114200)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_486', 'drugName': 'Rivastigmine', 'drugIsApproved': True, 'newLinkedTargets_string': 'BCHE (ENSG00... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1314 | Q1 | Is RRM2 a druggable gene? | There are currently 6 approved drugs which target RRM2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%RRM2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4', 'drugName': 'Gemcitabine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'POLA1 (ENSG00000101868), POLD4 (ENSG00000175482), POLD3 (ENSG00000077514), POLD1 (ENSG00000062822), POLD2 (ENSG00000106628), POLE (ENSG00000177084), POLA2 (ENSG00000014138), PRIM1 (ENSG00000198... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.825 | Q1 | Is LNPEP a druggable gene? | There are currently no approved drugs targeting LNPEP, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%LNPEP %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), L... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.892 | Q1 | Is MME a druggable gene? | There are currently 2 approved drugs which target MME, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MME %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5090', 'drugName': 'Racecadotril', 'drugIsApproved': True, 'newLinkedTargets_string': 'MME (ENSG00000196549)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_1487', 'drugName': 'Sacubitril', 'drugIsApproved': True, 'newLinkedTargets_string': 'MME (ENSG00000196549)', 'maxClinical... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.68 | Q1 | Is AOPEP a druggable gene? | There are currently no approved drugs targeting AOPEP, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%AOPEP %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_582', 'drugName': 'Tosedostat', 'drugIsApproved': False, 'newLinkedTargets_string': 'ANPEP (ENSG00000166825), NPEPPS (ENSG00000141279), RNPEP (ENSG00000176393), METAP1 (ENSG00000164024), LNPEP (ENSG00000113441), DNPEP (ENSG00000123992), ENPEP (ENSG00000138792), XPNPEP1 (ENSG00000108039), L... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1111 | Q1 | Is POLR3A a druggable gene? | There are currently no approved drugs targeting POLR3A, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%POLR3A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3830', 'drugName': 'Tas-106', 'drugIsApproved': False, 'newLinkedTargets_string': 'POLR1A (ENSG00000068654), POLR3A (ENSG00000148606), POLR2A (ENSG00000181222)', 'maxClinicalTrialPhase': 2}, {'UUID': 'DrugGeneTargets_v2_3831', 'drugName': 'Tas-106', 'drugIsApproved': False, 'newLinkedTarge... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.249 | Q1 | Is CDK9 a druggable gene? | There are currently no approved drugs targeting CDK9, but there are 11 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%CDK9 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5626', 'drugName': 'Alvocidib', 'drugIsApproved': False, 'newLinkedTargets_string': 'CDK1 (ENSG00000170312), CDK7 (ENSG00000134058), CDK9 (ENSG00000136807), CDK6 (ENSG00000105810), CDK2 (ENSG00000123374), CDK4 (ENSG00000135446)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_47... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.879 | Q1 | Is MET a druggable gene? | There are currently 8 approved drugs which target MET, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%MET %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1908', 'drugName': 'Tepotinib Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'MET (ENSG00000105976)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4806', 'drugName': 'Cabozantinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'MET (ENSG00000105976), ... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.675 | Q1 | Is IL15RA a druggable gene? | There are currently no approved drugs targeting IL15RA, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL15RA %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_1651', 'drugName': 'Recombinant Human Interleukin-15', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL2RG (ENSG00000147168), IL2RB (ENSG00000100385), IL15RA (ENSG00000134470)', 'maxClinicalTrialPhase': 2}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1370 | Q1 | Is SLC39A6 a druggable gene? | There are currently no approved drugs targeting SLC39A6, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%SLC39A6 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2652', 'drugName': 'Ladiratuzumab Vedotin', 'drugIsApproved': False, 'newLinkedTargets_string': 'TUBB4B (ENSG00000188229), TUBB1 (ENSG00000101162), TUBA3C (ENSG00000198033), TUBA4A (ENSG00000127824), TUBB3 (ENSG00000258947), TUBA1A (ENSG00000167552), TUBB4A (ENSG00000104833), TUBB8 (ENSG00... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1173 | Q1 | Is PSMC4 a druggable gene? | There are currently 4 approved drugs which target PSMC4, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PSMC4 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_559', 'drugName': 'Bortezomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.555 | Q1 | Is GRM2 a druggable gene? | There are currently no approved drugs targeting GRM2, but there are 6 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%GRM2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_6227', 'drugName': 'Pomaglumetad Methionil', 'drugIsApproved': False, 'newLinkedTargets_string': 'GRM2 (ENSG00000164082), GRM3 (ENSG00000198822)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_6226', 'drugName': 'Pomaglumetad Methionil', 'drugIsApproved': False, 'newLinkedTarge... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.602 | Q1 | Is HRH1 a druggable gene? | There are currently over 100 approved drugs which target HRH1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HRH1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3567', 'drugName': 'Azelastine Hydrochloride', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_4572', 'drugName': 'Thenalidine', 'drugIsApproved': True, 'newLinkedTargets_string': 'HRH1 (ENSG00000196639)... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.125 | Q1 | Is BTK a druggable gene? | There are currently 4 approved drugs which target BTK, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%BTK %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_593', 'drugName': 'Acalabrutinib', 'drugIsApproved': True, 'newLinkedTargets_string': 'BTK (ENSG00000010671)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_6297', 'drugName': 'Acalabrutinib Maleate', 'drugIsApproved': True, 'newLinkedTargets_string': 'BTK (ENSG00000010671)', '... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1061 | Q1 | Is PDE8A a druggable gene? | There are currently 4 approved drugs which target PDE8A, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PDE8A %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_766', 'drugName': 'Flavoxate', 'drugIsApproved': True, 'newLinkedTargets_string': 'PDE8B (ENSG00000113231), PDE8A (ENSG00000073417), PDE7A (ENSG00000205268), PDE7B (ENSG00000171408), PDE4A (ENSG00000065989), PDE4D (ENSG00000113448), PDE4B (ENSG00000184588), PDE4C (ENSG00000105650)', 'maxCl... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.679 | Q1 | Is IL18 a druggable gene? | There are currently no approved drugs targeting IL18, but there are 3 drugs in clinical trials indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IL18 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2500', 'drugName': 'Tadekinig Alfa', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL18 (ENSG00000150782)', 'maxClinicalTrialPhase': 3}, {'UUID': 'DrugGeneTargets_v2_5480', 'drugName': 'Gsk-1070806', 'drugIsApproved': False, 'newLinkedTargets_string': 'IL18 (ENSG00000150782)', 'maxC... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.994 | Q1 | Is NPC1L1 a druggable gene? | There is 1 drug, Ezetimibe, that targets NPC1L1, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%NPC1L1 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_4425', 'drugName': 'Ezetimibe', 'drugIsApproved': True, 'newLinkedTargets_string': 'NPC1L1 (ENSG00000015520)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.573 | Q1 | Is HBB a druggable gene? | There is 1 drug, Voxelotor, that targets HBB, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%HBB %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_2318', 'drugName': 'Voxelotor', 'drugIsApproved': True, 'newLinkedTargets_string': 'HBA1 (ENSG00000206172), HBA2 (ENSG00000188536), HBB (ENSG00000244734)', 'maxClinicalTrialPhase': 4}, {'UUID': 'DrugGeneTargets_v2_5739', 'drugName': 'Betibeglogene Autotemcel', 'drugIsApproved': False, 'new... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1132 | Q1 | Is PRKAG2 a druggable gene? | There are currently no approved drugs targeting PRKAG2, but there is 1 drug in a clinical trial indicating that it may be a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PRKAG2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_5888', 'drugName': 'Acadesine', 'drugIsApproved': False, 'newLinkedTargets_string': 'PRKAA2 (ENSG00000162409), PRKAB2 (ENSG00000131791), PRKAG1 (ENSG00000181929), PRKAG2 (ENSG00000106617), PRKAB1 (ENSG00000111725), PRKAA1 (ENSG00000132356), PRKAG3 (ENSG00000115592)', 'maxClinicalTrialPhase... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.1171 | Q1 | Is PSMC2 a druggable gene? | There are currently 4 approved drugs which target PSMC2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%PSMC2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_559', 'drugName': 'Bortezomib', 'drugIsApproved': True, 'newLinkedTargets_string': 'PSMD1 (ENSG00000173692), PSMB2 (ENSG00000126067), PSMB1 (ENSG00000008018), PSMB5 (ENSG00000100804), PSMB8 (ENSG00000204264), PSMB9 (ENSG00000240065), PSMB6 (ENSG00000142507), PSMD14 (ENSG00000115233), PSMA1... | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
Q1.658 | Q1 | Is IFNGR2 a druggable gene? | There is 1 drug, Interferon Gamma-1B, that targets IFNGR2, indicating that it is a druggable gene. | SELECT DISTINCT UUID, drugName, drugIsApproved, newLinkedTargets_string, maxClinicalTrialPhase
FROM `{project_id}.{dataset_name}.DrugGeneTargets_ComprehensiveAnnotations_updated`
WHERE newLinkedTargets_string LIKE "%IFNGR2 %"
ORDER BY maxClinicalTrialPhase DESC
LIMIT 100
| [{'UUID': 'DrugGeneTargets_v2_3679', 'drugName': 'Interferon Gamma-1B', 'drugIsApproved': True, 'newLinkedTargets_string': 'IFNGR2 (ENSG00000159128), IFNGR1 (ENSG00000027697)', 'maxClinicalTrialPhase': 4}] | general | Similarity Search, Order By, Distinct | Approval Status, Genetic Target |
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